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Target
Bromodomain-containing protein 4 [342-460]
Ligand
BDBM318461
Substrate
n/a
Meas. Tech.
AlphaScreen Assay A1
IC50
<100±n/a nM
Citation
 Combs, AP; Sparks, RB; Maduskuie, Jr., TP; Rodgers, JD Tricyclic heterocycles as BET protein inhibitors US Patent  US10464947 Publication Date 11/5/2019 
Target
Name:
Bromodomain-containing protein 4 [342-460]
Synonyms:
BRD4 | BRD4-BD2 (aa 342-460) | BRD4_HUMAN | Bromodomain containing 4 (aa 342-460) | Bromodomain-containing protein 4 (BRD4)(BD2) | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
13783.81
Organism:
Homo sapiens (Human)
Description:
a.a. 342-460 (BRD4-BD2)
Residue:
119
Sequence:
PAPEKSSKVSEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDE
  
Inhibitor
Name:
BDBM318461
Synonyms:
7-(3,5-Dimethylisoxazol-4-yl)-4-(3-methoxyphenyl)-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2(1H)-one | US10464947, Example 6 | US11498926, Example 6 | US9624241, Example 6
Type:
Small organic molecule
Emp. Form.:
C21H19N3O4
Mol. Mass.:
377.3933
SMILES:
COc1cccc(c1)C1COc2c(ccc3[nH]c(=O)n1c23)-c1c(C)noc1C |(-2.82,6.93,;-2.82,5.39,;-1.48,4.62,;-.15,5.39,;1.18,4.62,;1.18,3.08,;-.15,2.31,;-1.48,3.08,;-.15,.77,;-1.48,,;-1.48,-1.54,;-.15,-2.31,;-.15,-3.85,;1.18,-4.62,;2.52,-3.85,;2.52,-2.31,;3.85,-1.54,;2.72,,;3.49,1.33,;1.18,,;1.18,-1.54,;-1.48,-4.62,;-1.48,-6.16,;-.15,-6.93,;-2.95,-6.64,;-3.85,-5.39,;-2.95,-4.14,;-3.72,-2.81,)|
Structure:
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