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Target
Bromodomain-containing protein 4 [42-168]
Ligand
BDBM318521
Substrate
n/a
Meas. Tech.
AlphaScreen Assay A2
IC50
<100±n/a nM
Citation
 Combs, AP; Sparks, RB; Maduskuie, Jr., TP; Rodgers, JD Tricyclic heterocycles as BET protein inhibitors US Patent  US10464947 Publication Date 11/5/2019 
Target
Name:
Bromodomain-containing protein 4 [42-168]
Synonyms:
BRD4 | BRD4 BD1 (aa 42-168) | BRD4_HUMAN | Bromodomain-containing protein 4 Bromo Domain 1 | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
15054.68
Organism:
Homo sapiens (Human)
Description:
O60885[42-168]
Residue:
127
Sequence:
STNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE
  
Inhibitor
Name:
BDBM318521
Synonyms:
7-(3,5-Dimethylisoxazol-4-yl)-5-(hydroxymethyl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2(1H)-one | US10464947, Example 62B | US11498926, Example 62B | US9624241, Example 62B
Type:
Small organic molecule
Emp. Form.:
C20H18N4O4
Mol. Mass.:
378.3813
SMILES:
Cc1noc(C)c1-c1ccc2[nH]c(=O)n3C(C(CO)Oc1c23)c1ccccn1 |(-3.57,-2.04,;-2.8,-3.37,;-3.7,-4.62,;-2.8,-5.87,;-1.33,-5.39,;,-6.16,;-1.33,-3.85,;,-3.08,;1.33,-3.85,;2.67,-3.08,;2.67,-1.54,;4,-.77,;2.87,.77,;3.64,2.1,;1.33,.77,;,1.54,;-1.33,.77,;-2.67,1.54,;-4,.77,;-1.33,-.77,;,-1.54,;1.33,-.77,;,3.08,;1.33,3.85,;1.33,5.39,;,6.16,;-1.33,5.39,;-1.33,3.85,)|
Structure:
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