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Target
Bromodomain-containing protein 4 [42-168]
Ligand
BDBM318537
Substrate
n/a
Meas. Tech.
AlphaScreen Assay A2
IC50
<100±n/a nM
Citation
 Combs, AP; Sparks, RB; Maduskuie, Jr., TP; Rodgers, JD Tricyclic heterocycles as BET protein inhibitors US Patent  US10464947 Publication Date 11/5/2019 
Target
Name:
Bromodomain-containing protein 4 [42-168]
Synonyms:
BRD4 | BRD4 BD1 (aa 42-168) | BRD4_HUMAN | Bromodomain-containing protein 4 Bromo Domain 1 | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
15054.68
Organism:
Homo sapiens (Human)
Description:
O60885[42-168]
Residue:
127
Sequence:
STNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE
  
Inhibitor
Name:
BDBM318537
Synonyms:
US10464947, Example 83 | US11498926, Example 83 | US9624241, Example 83 | tert-butyl 4-[(4S)-7-(3,5- dimethylisoxazol-4-yl)-2-oxo- 4-pyridin-2-yl-1,2,4,5- tetrahydroimidazo[1,5,4- de][1,4]benzoxazin-9-yl]-3,6- dihydropyridine-1(2H)- carboxylate 2,2,2- trifluoroacetate
Type:
Small organic molecule
Emp. Form.:
C29H31N5O5
Mol. Mass.:
529.5869
SMILES:
Cc1noc(C)c1-c1cc(C2=CCN(CC2)C(=O)OC(C)(C)C)c2[nH]c(=O)n3[C@H](COc1c23)c1ccccn1 |wD:28.37,t:11,(-6.81,-3.48,;-5.35,-3.96,;-4.87,-5.42,;-3.33,-5.42,;-2.86,-3.96,;-1.39,-3.48,;-4.1,-3.05,;-4.1,-1.51,;-2.77,-.74,;-2.77,.8,;-1.44,1.57,;-1.44,3.11,;-.1,3.88,;1.23,3.11,;1.23,1.57,;-.1,.8,;2.56,3.88,;2.56,5.42,;3.9,3.11,;5.23,3.88,;5.23,5.42,;6.57,4.65,;6.57,3.11,;-4.1,1.57,;-4.67,3,;-6.21,3,;-6.98,4.34,;-6.77,1.57,;-8.11,.8,;-8.11,-.74,;-6.77,-1.51,;-5.44,-.74,;-5.44,.8,;-9.44,1.57,;-10.77,.8,;-12.11,1.57,;-12.11,3.11,;-10.77,3.88,;-9.44,3.11,)|
Structure:
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