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Target
Proto-oncogene Wnt-1
Ligand
BDBM385277
Substrate
n/a
Meas. Tech.
The screening assay for Wnt activity
EC50
1449±n/a nM
Citation
 KC, SK; Mittapalli, GK; Hofilena, BJ; Marakovits, JT; Chiruta, C; Mak, CC; Cao, J Isoquinolin-3-yl carboxamides and preparation and use thereof US Patent  US10508099 Publication Date 12/17/2019 
Target
Name:
Proto-oncogene Wnt-1
Synonyms:
INT1 | Proto-oncogene Int-1 homolog | WNT1 | WNT1_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41006.01
Organism:
Homo sapiens (human)
Description:
P04628
Residue:
370
Sequence:
MGLWALLPGWVSATLLLALAALPAALAANSSGRWWGIVNVASSTNLLTDSKSLQLVLEPSLQLLSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNCPTAPGPHLFGKIVNRGCRETAFIFAITSAGVTHSVARSCSEGSIESCTCDYRRRGPGGPDWHWGGCSDNIDFGRLFGREFVDSGEKGRDLRFLMNLHNNEAGRTTVFSEMRQECKCHGMSGSCTVRTCWMRLPTLRAVGDVLRDRFDGASRVLYGNRGSNRASRAELLRLEPEDPAHKPPSPHDLVYFEKSPNFCTYSGRLGTAGTAGRACNSSSPALDGCELLCCGRGHRTRTQRVTERCNCTFHWCCHVSCRNCTHTRVLHECL
  
Inhibitor
Name:
BDBM385277
Synonyms:
US10287267, Compound 964 | US10508099, Compound 964 | US10556885, Compound 964 | US11174244, Compound 964 | US11673881, Compound 964
Type:
Small organic molecule
Emp. Form.:
C25H25N5O3S
Mol. Mass.:
475.563
SMILES:
Cn1cc(cn1)-c1ccc2cnc(NC(=O)C3CCN(CC3)S(=O)(=O)c3ccccc3)cc2c1
Structure:
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