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Target
E3 ubiquitin-protein ligase ORTHRUS 5
Ligand
BDBM426627
Substrate
n/a
Meas. Tech.
beta-lactamase assay
Ki
9120±n/a nM
Citation
 Chen, Y; Pemberton, OA; Renslo, A; Jaishankar, P Beta-lactamase inhibitors, formulations, and uses thereof US Patent  US10543221 Publication Date 1/28/2020 
Target
Name:
E3 ubiquitin-protein ligase ORTHRUS 5
Synonyms:
ORTH5 | ORTH5_ARATH | Protein VARIANT IN METHYLATION 2 | RING-type E3 ubiquitin transferase ORTHRUS 5 | VIM2
Type:
Protein
Mol. Mass.:
68730.62
Organism:
Mouse-ear cress
Description:
Q680I0
Residue:
623
Sequence:
MAIQTQLPCDGDGVCMRCQVNPPSEETLTCGTCVTPWHVSCLLPESLASSTGDWECPDCSGVVVPSAAPGTGISGPESSGSVLVTAIRAIQADVTLTEAEKAKKRQRLMSGGGDDGVDDEEKKKLEIFCSICIQLPERPVTTPCGHNFCLKCFEKWAVGQGKLTCMICRSKIPRHVAKNPRINLALVSAIRLANVTKCSGEATAAKVHHIIRNQDRPDKAFTTERAVKTGKANAASGKFFVTIPRDHFGPIPAANDVTRNQGVLVGESWEDRQECRQWGVHFPHVAGIAGQAAVGAQSVALSGGYDDDEDHGEWFLYTGSGGRDLSGNKRVNKIQSSDQAFKNMNEALRLSCKMGYPVRVVRSWKEKRSAYAPAEGVRYDGVYRIEKCWSNVGVQGLHKMCRYLFVRCDNEPAPWTSDEHGDRPRPLPDVPELENATDLFVRKESPSWGFDEAEGRWKWMKSPPVSRMALDTEERKKNKRAKKGNNAMKARLLKEFSCQICRKVLSLPVTTPCAHNFCKACLEAKFAGITQLRDRSNGVRKLRAKKNIMTCPCCTTDLSEFLQNPQVNREMMEIIENFKKSEEEAEVAESSNISEEEGEEESEPPTKKIKMDKNSVGGTSLSA
  
Inhibitor
Name:
BDBM426627
Synonyms:
US10543221, Compound 994943 | US10543221, Formula 14
Type:
Small organic molecule
Emp. Form.:
C10H10NO4P
Mol. Mass.:
239.1645
SMILES:
OP(O)(=O)Cc1cc(=O)[nH]c2ccccc12
Structure:
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