Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM431928
Substrate
n/a
Meas. Tech.
IPOne assay
EC50
27.0±n/a nM
Citation
 Eckhardt, M; Wagner, H; Peters, S Indanylaminoazadihydrobenzofuranylacetic acids, pharmaceutical compositions for the treatment of diabetes US Patent  US10550127 Publication Date 2/4/2020 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM431928
Synonyms:
((S)-6-{(R)-4-[2,6-Dimethyl-4-(tetrahydro-furan-3-ylmethoxy)-phenyl]-7-fluoro-indan-1-ylamino}-2,3-dihydro-furo[3,2-c]pyridin-3-yl)-acetic Acid | US10550127, Example 14
Type:
Small organic molecule
Emp. Form.:
C31H33FN2O5
Mol. Mass.:
532.6025
SMILES:
Cc1cc(OCC2CCOC2)cc(C)c1-c1ccc(F)c2[C@@H](CCc12)Nc1cc2OC[C@@H](CC(O)=O)c2cn1 |r,wU:31.35,wD:21.28,(-2.14,-2.11,;-3.65,-1.79,;-4.68,-2.94,;-6.19,-2.62,;-7.22,-3.76,;-8.72,-3.44,;-9.2,-1.98,;-8.29,-.73,;-9.2,.52,;-10.66,.04,;-10.66,-1.5,;-6.66,-1.15,;-5.63,-.01,;-6.11,1.46,;-4.12,-.33,;-3.09,.82,;-3.57,2.28,;-2.54,3.43,;-1.03,3.11,;-0,4.25,;-.56,1.64,;.85,1.01,;.69,-.52,;-.82,-.84,;-1.59,.5,;2.18,1.79,;3.52,1.01,;4.85,1.79,;6.19,1.01,;7.65,1.49,;8.55,.24,;7.65,-1,;8.13,-2.47,;9.63,-2.79,;10.66,-1.64,;10.11,-4.25,;6.19,-.53,;4.85,-1.29,;3.52,-.53,)|
Structure:
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