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Target
Histone-lysine N-methyltransferase SMYD3
Ligand
BDBM432841
Substrate
n/a
Meas. Tech.
SMYD3 Biochemical Assay
IC50
1.90±n/a nM
Citation
 Mitchell, LH; Bell, AS; Chesworth, R; Foley, MA; Kuntz, KW; Mills, JE; Munchhof, MJ Substituted piperidine compounds US Patent  US10577363 Publication Date 3/3/2020 
Target
Name:
Histone-lysine N-methyltransferase SMYD3
Synonyms:
SET and MYND domain-containing protein 3 | SMYD3 | SMYD3_HUMAN | ZMYND1 | ZNFN3A1 | Zinc finger MYND domain-containing protein 1
Type:
Enzyme
Mol. Mass.:
49101.22
Organism:
Homo sapiens (Human)
Description:
Q9H7B4-2
Residue:
428
Sequence:
MEPLKVEKFATAKRGNGLRAVTPLRPGELLFRSDPLAYTVCKGSRGVVCDRCLLGKEKLMRCSQCRVAKYCSAKCQKKAWPDHKRECKCLKSCKPRYPPDSVRLLGRVVFKLMDGAPSESEKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLFEAFAKVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEECDANIRAS
  
Inhibitor
Name:
BDBM432841
Synonyms:
N-((2S,4S)-1-(((1-benzylpiperidin-4- yl)methyl)sulfonyl)-2-methylpiperidin-4- yl)-5-cyclopropylisoxazole-3-carboxamide | US10577363, Compound 544
Type:
Small organic molecule
Emp. Form.:
C26H36N4O4S
Mol. Mass.:
500.653
SMILES:
C[C@H]1C[C@H](CCN1S(=O)(=O)CC1CCN(Cc2ccccc2)CC1)NC(=O)c1cc(on1)C1CC1 |r|
Structure:
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