Reaction Details Report a problem with these data
Target
Vascular endothelial growth factor A
Ligand
BDBM102336
Substrate
n/a
Meas. Tech.
ELISA Assay
IC50
27400±n/a nM
Citation
 Gardner, JH; Shalwitz, R; Wu, S Prolyl hydroxylase inhibitors US Patent  US10562854 Publication Date 2/18/2020 
Target
Name:
Vascular endothelial growth factor A
Synonyms:
VEGF | VEGF-A | VEGFA | VEGFA_HUMAN | VPF | Vascular endothelial growth factor (VEGF) | Vascular endothelial growth factor A (VEGF) | Vascular endothelial growth factor A (VEGF2) | Vascular permeability factor
Type:
Protein
Mol. Mass.:
27063.81
Organism:
Homo sapiens (Human)
Description:
P15692
Residue:
395
Sequence:
MTDRQTDTAPSPSYHLLPGRRRTVDAAASRGQGPEPAPGGGVEGVGARGVALKLFVQLLGCSRFGGAVVRAGEAEPSGAARSASSGREEPQPEEGEEEEEKEEERGPQWRLGARKPGSWTGEAAVCADSAPAARAPQALARASGRGGRVARRGAEESGPPHSPSRRGSASRAGPGRASETMNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR
  
Inhibitor
Name:
BDBM102336
Synonyms:
US10562854, No. C17 | US8536181, C17 | US9278930, C17
Type:
Small organic molecule
Emp. Form.:
C20H26N2O2
Mol. Mass.:
326.4326
SMILES:
CC1CCC(CC1)NCc1ccn(Cc2ccccc2)c(=O)c1O |(8.08,,;6.54,,;5.78,-1.33,;4.23,-1.33,;3.47,,;4.23,1.33,;5.78,1.33,;1.93,,;1.15,1.33,;-.38,1.33,;-1.15,2.67,;-2.69,2.67,;-3.47,1.33,;-5,1.33,;-5.78,,;-7.31,,;-8.08,-1.33,;-7.31,-2.67,;-5.78,-2.67,;-5,-1.33,;-2.69,,;-3.47,-1.33,;-1.15,,;-.38,-1.33,)|
Structure:
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