Reaction Details Report a problem with these data
Target
Egl nine homolog 1
Ligand
BDBM102344
Substrate
n/a
Meas. Tech.
Activity Assay
IC50
18000±n/a nM
Citation
 Gardner, JH; Shalwitz, R; Wu, S Prolyl hydroxylase inhibitors US Patent  US10562854 Publication Date 2/18/2020 
Target
Name:
Egl nine homolog 1
Synonyms:
C1orf12 | EGLN1 | EGLN1_HUMAN | Egl nine homolog 1 (EGLN1) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2) | Hypoxia-inducible factor prolyl hydroxylase 2 (HIFPH2) | Prolyl hydroxylase domain-containing protein 2 (PHD2)
Type:
Protein
Mol. Mass.:
46035.59
Organism:
Homo sapiens (Human)
Description:
Q9GZT9
Residue:
426
Sequence:
MANDSGGPGGPSPSERDRQYCELCGKMENLLRCSRCRSSFYCCKEHQRQDWKKHKLVCQGSEGALGHGVGPHQHSGPAPPAAVPPPRAGAREPRKAAARRDNASGDAAKGKVKAKPPADPAAAASPCRAAAGGQGSAVAAEAEPGKEEPPARSSLFQEKANLYPPSNTPGDALSPGGGLRPNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKPSDSVGKDVF
  
Inhibitor
Name:
BDBM102344
Synonyms:
US10562854, No. A18 | US8536181, A18 | US9278930, A18
Type:
Small organic molecule
Emp. Form.:
C20H26N2O3
Mol. Mass.:
342.432
SMILES:
OCc1ccccc1Cn1ccc(CN2CCCCCC2)c(O)c1=O
Structure:
Search PDB for entries with ligand similarity: