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Target
Chloroquine resistance transporter
Ligand
BDBM434958
Substrate
n/a
Meas. Tech.
Efficacy of ELQ-337 In Vitro
IC50
3.50±n/a nM
Citation
 Riscoe, M; Nilsen, A; Miley, G; Winter, R; Pou, S; Kelly, JX; Dodean, R Quinolone-3-diarylethers US Patent  US10584098 Publication Date 3/10/2020  Article 
Target
Name:
Chloroquine resistance transporter
Synonyms:
CRT | CRT_PLAFA | PfCRT
Type:
PROTEIN
Mol. Mass.:
48687.29
Organism:
Plasmodium falciparum
Description:
ChEMBL_1364181
Residue:
424
Sequence:
MKFASKKNNQKNSSKNDERYRELDNLVQEGNGSRLGGGSCLGKCAHVFKLIFKEIKDNIFIYILSIIYLSVCVMNKIFAKRTLNKIGNYSFVTSETHNFICMIMFFIVYSLFGNKKGNSKERHRSFNLQFFAISMLDACSVILAFIGLTRTTGNIQSFVLQLSIPINMFFCFLILRYRYHLYNYLGAVIIVVTIALVEMKLSFETQEENSIIFNLVLISALIPVCFSNMTREIVFKKYKIDILRLNAMVSFFQLFTSCLILPVYTLPFLKQLHLPYNEIWTNIKNGFACLFLGRNTVVENCGLGMAKLCDDCDGAWKTFALFSFFNICDNLITSYIIDKFSTMTYTIVSCIQGPAIAIAYYFKFLAGDVVREPRLLDFVTLFGYLFGSIIYRVGNIILERKKMRNEENEDSEGELTNVDSIITQ
  
Inhibitor
Name:
BDBM434958
Synonyms:
US10584098, Code ELQ-357
Type:
Small organic molecule
Emp. Form.:
C29H25ClF3NO5
Mol. Mass.:
559.961
SMILES:
Cc1nc2cc(CO)c(Cl)cc2c(OC(=O)C(C)(C)C)c1-c1ccc(Oc2ccc(OC(F)(F)F)cc2)cc1
Structure:
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