Reaction Details Report a problem with these data
Target
Diacylglycerol O-acyltransferase 2
Ligand
BDBM435303
Substrate
n/a
Meas. Tech.
Enzymatic Activity Assay
IC50
11.5±n/a nM
Citation
 Imbriglio, J; Liang, R; London, C; Marby, K; Tata, J; You, M; Xiong, Y Tetrahydroisoquinoline derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2 US Patent  US10568876 Publication Date 2/25/2020 
Target
Name:
Diacylglycerol O-acyltransferase 2
Synonyms:
ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | DGAT2_HUMAN | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase
Type:
Multi-pass membrane protein
Mol. Mass.:
43848.90
Organism:
Homo sapiens (Human)
Description:
Q96PD7
Residue:
388
Sequence:
MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN
  
Inhibitor
Name:
BDBM435303
Synonyms:
8-(((trans)-2-(3-methyl-1,2,4-oxadiazol-5- yl)cyclopropanecarboxamido)methyl)-N- propyl-5-(3-(trifluoromethyl)phenyl)-3,4- dihydroisoquinoline-2(1H)-carboxamide (mixture of 2 isomers) | US10568876, Example 66
Type:
Small organic molecule
Emp. Form.:
C28H30F3N5O3
Mol. Mass.:
541.5647
SMILES:
CCCNC(=O)N1CCc2c(C1)c(CNC(=O)[C@@H]1C[C@H]1c1nc(C)no1)ccc2-c1cccc(c1)C(F)(F)F |r|
Structure:
Search PDB for entries with ligand similarity: