Reaction Details Report a problem with these data
Target
Diacylglycerol O-acyltransferase 2
Ligand
BDBM435307
Substrate
n/a
Meas. Tech.
Enzymatic Activity Assay
IC50
20.4±n/a nM
Citation
Imbriglio, J; Liang, R; London, C; Marby, K; Tata, J; You, M; Xiong, Y Tetrahydroisoquinoline derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2 US Patent US10568876 Publication Date 2/25/2020
More Info.:
Target
Name:
Diacylglycerol O-acyltransferase 2
Synonyms:
ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | DGAT2_HUMAN | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase
Type:
Multi-pass membrane protein
Mol. Mass.:
43848.90
Organism:
Homo sapiens (Human)
Description:
Q96PD7
Residue:
388
Sequence:
MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN
Inhibitor
Name:
BDBM435307
Synonyms:
5-(3-methoxyphenyl)-8-(((trans-2- phenylcyclopropanecarboxamido)methyl)- N-propyl-3,4-dihydroisoquinoline-2(1H)- carboxamide (mixture of 2 isomers) | US10568876, Example 70
Type:
Small organic molecule
Emp. Form.:
C30H33N3O3
Mol. Mass.:
483.6013
SMILES:
CCNC(=O)N1CCc2c(C1)c(CNC(=O)[C@@H]1C[C@H]1c1ccccc1)ccc2-c1cccc(OC)c1 |r|