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Target
Diacylglycerol O-acyltransferase 2
Ligand
BDBM435324
Substrate
n/a
Meas. Tech.
Enzymatic Activity Assay
IC50
2286±n/a nM
Citation
 Imbriglio, J; Liang, R; London, C; Marby, K; Tata, J; You, M; Xiong, Y Tetrahydroisoquinoline derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2 US Patent  US10568876 Publication Date 2/25/2020 
Target
Name:
Diacylglycerol O-acyltransferase 2
Synonyms:
ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | DGAT2_HUMAN | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase
Type:
Multi-pass membrane protein
Mol. Mass.:
43848.90
Organism:
Homo sapiens (Human)
Description:
Q96PD7
Residue:
388
Sequence:
MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN
  
Inhibitor
Name:
BDBM435324
Synonyms:
N-((2-(2-(((trans)-2- (methoxymethyl)cyclopentyl)amino)-2- oxoethyl)-5-(3-(trifluoromethoxy)phenyl)- 1,2,3,4-tetrahydroisoquinolin-8-yl)methyl)- 2-(3-methyl-1,2,4-oxadiazol-5- yl)cyclopropanecarboxamide (mixture of 2 isomers) | US10568876, Example 86
Type:
Small organic molecule
Emp. Form.:
C33H38F3N5O5
Mol. Mass.:
641.6805
SMILES:
COC[C@H]1CCC[C@H]1NC(=O)CN1CCc2c(C1)c(CNC(=O)C1CC1c1nc(C)no1)ccc2-c1cccc(OC(F)(F)F)c1 |r|
Structure:
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