Reaction Details Report a problem with these data
Target
Neurotensin receptor type 1
Ligand
BDBM297526
Substrate
n/a
Meas. Tech.
NTR1 Ca2+ Flux Dose Response
EC50
>10000±n/a nM
Citation
 Pinkerton, AB; Hershberger, PM; Peddibhotla, S; Maloney, PR; Hedrick, MP Small molecule agonists of neurotensin receptor 1 US Patent  US10118902 Publication Date 11/6/2018 
Target
Name:
Neurotensin receptor type 1
Synonyms:
Dopamine receptor D2L/neurotensin receptor NTS1 | NTR1_HUMAN | NTRR | NTSR1 | Neurotensin receptor 1 | neurotensin receptor type 1
Type:
PROTEIN
Mol. Mass.:
46278.89
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1453811
Residue:
418
Sequence:
MRLNSSAPGTPGTPAADPFQRAQAGLEEALLAPGFGNASGNASERVLAAPSSELDVNTDIYSKVLVTAVYLALFVVGTVGNTVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLTLLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAVPMLFTMGEQNRSADGQHAGGLVCTPTIHTATVKVVIQVNTFMSFIFPMVVISVLNTIIANKLTVMVRQAAEQGQVCTVGGEHSTFSMAIEPGRVQALRHGVRVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTPFLYDFYHYFYMVTNALFYVSSTINPILYNLVSANFRHIFLATLACLCPVWRRRRKRPAFSRKADSVSSNHTLSSNATRETLY
  
Inhibitor
Name:
BDBM297526
Synonyms:
N-[4-[4-(2-dimethylamino- phenyl)-piperidin-1-yl]-2-(1- methyl-cyclopropyl)-quinazolin-6- yl]-N,N',N'-trimethyl-ethane-1,2- diamine | US10118902, Example 28 | US10584103, Example 28
Type:
Small organic molecule
Emp. Form.:
C30H42N6
Mol. Mass.:
486.6947
SMILES:
CN(C)CCN(C)c1ccc2nc(nc(N3CCC(CC3)c3ccccc3N(C)C)c2c1)C1(C)CC1
Structure:
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