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Target
Programmed cell death protein 1
Ligand
BDBM436122
Substrate
n/a
Meas. Tech.
Homogenous Time-Resolved Fluorescence (HTRF) Binding Assay
IC50
5000±n/a nM
Citation
 Yeung, K; Grant-Young, KA; Zhu, J; Saulnier, MG; Frennesson, DB; Meng, Z; Scola, PM 1,3-dihydroxy-phenyl derivatives useful as immunomodulators US Patent  US10590105 Publication Date 3/17/2020 
Target
Name:
Programmed cell death protein 1
Synonyms:
CD_antigen=CD279 | PD1 | PDCD1 | PDCD1_HUMAN | Programmed cell death protein 1 | Protein PD-1 | hPD-1
Type:
PROTEIN
Mol. Mass.:
31650.07
Organism:
Homo sapiens
Description:
ChEMBL_108437
Residue:
288
Sequence:
MQIPQAPWPVVWAVLQLGWRPGWFLDSPDRPWNPPTFSPALLVVTEGDNATFTCSFSNTSESFVLNWYRMSPSNQTDKLAAFPEDRSQPGQDCRFRVTQLPNGRDFHMSVVRARRNDSGTYLCGAISLAPKAQIKESLRAELRVTERRAEVPTAHPSPSPRPAGQFQTLVVGVVGGLLGSLVLLVWVLAVICSRAARGTIGARRTGQPLKEDPSAVPVFSVDYGELDFQWREKTPEPPVPCVPEQTEYATIVFPSGMGTSSPARRGSADGPRSAQPLRPEDGHCSWPL
  
Inhibitor
Name:
BDBM436122
Synonyms:
US10590105, Example 1014
Type:
Small organic molecule
Emp. Form.:
C36H35ClN6O5
Mol. Mass.:
667.153
SMILES:
Cc1c(COc2cc(OCc3cncc(c3)C#N)c(CN[C@@H](CCCNC(N)=N)C(O)=O)cc2Cl)cccc1-c1ccc2occc2c1 |r|
Structure:
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