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Target
Estrogen receptor [307-554]
Ligand
BDBM361526
Substrate
n/a
Meas. Tech.
Binding Assay
IC50
1.20±n/a nM
Citation
 Nissink, JW; Scott, JS; Moss, TA; Hughes, SJ; Barlaam, BC; Yang, B Selective estrogen receptor down-regulators US Patent  US10590132 Publication Date 3/17/2020 
Target
Name:
Estrogen receptor [307-554]
Synonyms:
ESR | ESR1 | ESR1_HUMAN | Estrogen receptor(ER) (aa 307-554) | NR3A1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
28281.50
Organism:
Homo sapiens (Human)
Description:
aa 307-554
Residue:
248
Sequence:
ALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHAPTS
  
Inhibitor
Name:
BDBM361526
Synonyms:
2,2-difluoro-3- ((1R,3R)-1-(6- fluoro-3-(2- ((3- fluoropropyl) amino)ethoxy)- 2- methylphenyl)- 3-methyl- 1,3,4,9- tetrahydro-2H- pyrido[3,4- b]indol-2- yl)propanoic acid | US10221173, Example 118 | US10590132, Example 118 | US11046689, Example 118
Type:
Small organic molecule
Emp. Form.:
C27H31F4N3O3
Mol. Mass.:
521.547
SMILES:
C[C@@H]1Cc2c([nH]c3ccccc23)[C@H](N1CC(F)(F)C(O)=O)c1c(F)ccc(OCCNCCCF)c1C |r|
Structure:
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