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Target
Lysine-specific histone demethylase 1A
Ligand
BDBM439099
Substrate
n/a
Meas. Tech.
FL-LSD1 LC-MS Assay
IC50
67.0±n/a nM
Citation
 Du-Cuny, L; Xiao, Q; Xun, G; Zheng, Q Substituted 5-cyanoindole compounds and uses thereof US Patent  US10604502 Publication Date 3/31/2020 
Target
Name:
Lysine-specific histone demethylase 1A
Synonyms:
AOF2 | BRAF35-HDAC complex protein BHC110 | Flavin-containing amine oxidase domain-containing protein 2 | KDM1 | KDM1A | KDM1A_HUMAN | KIAA0601 | LSD1 | Lysine-specific demethylase 1 (LSD1) | Lysine-specific histone demethylase 1 | Lysine-specific histone demethylase 1 (LSD1)
Type:
Enzyme
Mol. Mass.:
92901.01
Organism:
Homo sapiens (Human)
Description:
O60341
Residue:
852
Sequence:
MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTPRKKEPPRASPPGGLAEPPGSAGPQAGPTVVPGSATPMETGIAETPEGRRTSRRKRAKVEYREMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSGVEGAAFQSRLPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTFEATLQQLEAPYNSDTVLVHRVHSYLERHGLINFGIYKRIKPLPTKKTGKVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQEKHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKELHQQYKEASEVKPPRDITAEFLVKSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTASGCEVIAVNTRSTSQTFIYKCDAVLCTLPLGVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWNLYKAPILLALVAGEAAGIMENISDDVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPSIPGAPQPIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGAMYTLPRQATPGVPAQQSPSM
  
Inhibitor
Name:
BDBM439099
Synonyms:
US10604502, Ex # 87
Type:
Small organic molecule
Emp. Form.:
C23H24BrN3O
Mol. Mass.:
438.36
SMILES:
Cc1cc2n(cc(-c3ccc(Br)c(N)c3C)c2cc1C#N)[C@H]1CC[C@H](O)CC1 |r,wU:24.27,wD:21.23,(-3.95,-1.54,;-2.61,-.77,;-1.28,-1.54,;.06,-.77,;1.52,-1.25,;2.43,,;1.52,1.25,;2,2.71,;.97,3.86,;1.44,5.32,;2.95,5.64,;3.42,7.1,;3.98,4.5,;5.49,4.82,;3.5,3.03,;4.53,1.89,;.06,.77,;-1.28,1.54,;-2.61,.77,;-3.95,1.54,;-5.49,1.54,;2,-2.71,;.97,-3.86,;1.44,-5.32,;2.95,-5.64,;3.42,-7.1,;3.98,-4.5,;3.5,-3.03,)|
Structure:
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