Reaction Details Report a problem with these data
Target
Bromodomain-containing protein 4 [57-168]
Ligand
BDBM439513
Substrate
n/a
Meas. Tech.
TR-FRET Assay
Ki
284±n/a nM
Citation
 Hasvold, LA; Liu, D; McDaniel, KF; Pratt, J; Sheppard, G; Wang, L Bromodomain inhibitors US Patent  US10633379 Publication Date 4/28/2020 
Target
Name:
Bromodomain-containing protein 4 [57-168]
Synonyms:
BRD4 | BRD4_HUMAN | Bromodomain-containing protein 4 (BRD4) | Bromodomain-containing protein 4 (BRD4)(aa 57-168) | Bromodomain-containing protein 4 (BRD4-BD1) | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
13496.03
Organism:
Homo sapiens (Human)
Description:
BDI: amino acids K57-E168
Residue:
112
Sequence:
KRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE
  
Inhibitor
Name:
BDBM439513
Synonyms:
US10633379, Example 49
Type:
Small organic molecule
Emp. Form.:
C27H27ClFN3O4
Mol. Mass.:
511.972
SMILES:
CCNC(=O)c1cc2c(cn(C)c(=O)c2[nH]1)-c1cc(ccc1Oc1c(C)cc(F)cc1Cl)C(C)(C)O
Structure:
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