Reaction Details Report a problem with these data
Target
Proto-oncogene Wnt-1
Ligand
BDBM445775
Substrate
n/a
Meas. Tech.
Wnt activity assay
IC50
23.0±n/a nM
Citation
 Hood, J; Kumar KC, S; Wallace, DM; Mittapalli, GK; Hofilena, BJ; Mak, CC; Bollu, V; Eastman, B 5-substituted indazole-3-carboxamides and preparation and use thereof US Patent  US10669240 Publication Date 6/2/2020 
Target
Name:
Proto-oncogene Wnt-1
Synonyms:
INT1 | Proto-oncogene Int-1 homolog | WNT1 | WNT1_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41006.01
Organism:
Homo sapiens (human)
Description:
P04628
Residue:
370
Sequence:
MGLWALLPGWVSATLLLALAALPAALAANSSGRWWGIVNVASSTNLLTDSKSLQLVLEPSLQLLSRKQRRLIRQNPGILHSVSGGLQSAVRECKWQFRNRRWNCPTAPGPHLFGKIVNRGCRETAFIFAITSAGVTHSVARSCSEGSIESCTCDYRRRGPGGPDWHWGGCSDNIDFGRLFGREFVDSGEKGRDLRFLMNLHNNEAGRTTVFSEMRQECKCHGMSGSCTVRTCWMRLPTLRAVGDVLRDRFDGASRVLYGNRGSNRASRAELLRLEPEDPAHKPPSPHDLVYFEKSPNFCTYSGRLGTAGTAGRACNSSSPALDGCELLCCGRGHRTRTQRVTERCNCTFHWCCHVSCRNCTHTRVLHECL
  
Inhibitor
Name:
BDBM445775
Synonyms:
US10669240, Compound 71
Type:
Small organic molecule
Emp. Form.:
C27H27F2N7O
Mol. Mass.:
503.5464
SMILES:
FC1(F)CN(C1)c1ccc(NC(=O)c2n[nH]c3ccc(cc23)-c2cncc(CN3CCCCC3)c2)cn1
Structure:
Search PDB for entries with ligand similarity: