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Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM446500
Substrate
n/a
Meas. Tech.
Indoleamine-2,3-Dioxygenase 1 Inhibitory Activity
IC50
5500±n/a nM
Citation
 Meng, X; Chen, Y; Li, Z; Lu, D; Zhang, M Use of aza-tryptanthrin derivatives as inhibitors of IDO1 and/or TDO US Patent  US10669273 Publication Date 6/2/2020 
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Homo sapiens (Human)
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
  
Inhibitor
Name:
BDBM446500
Synonyms:
11-(hydroxyimino)-9-methoxypyrido[2′,3′:4,5]pyrimido[1,2-α]indole-5(11H)-one | US10669273, Compound CY-1-15
Type:
Small organic molecule
Emp. Form.:
C15H10N4O3
Mol. Mass.:
294.2649
SMILES:
COc1ccc-2c(c1)C(=NO)c1nc3ncccc3c(=O)n-21 |w:9.10|
Structure:
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