Reaction Details Report a problem with these data
Target
Amyloid-beta precursor protein [672-713]
Ligand
BDBM446528
Substrate
n/a
Meas. Tech.
gamma-Secretase Assay
EC50
14.0±n/a nM
Citation
 Bartels, B; Jakob-Roetne, R; Limberg, A; Neidhart, W; Ratni, H; Steiner, S; Reutlinger, M Fused pyrimidine derivatives US Patent  US10669276 Publication Date 6/2/2020 
Target
Name:
Amyloid-beta precursor protein [672-713]
Synonyms:
A4 | A4_HUMAN | AD1 | APP | Amyloid-beta precursor protein aa 672-713 | Amyloid-beta protein 42
Type:
Enzyme Catalytic Domain
Mol. Mass.:
4512.53
Organism:
Homo sapiens (Human)
Description:
P05067[672-713]
Residue:
42
Sequence:
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
  
Inhibitor
Name:
BDBM446528
Synonyms:
7-(3,3-Difluorocyclobutyl)-N2-(5-methoxy-6-(4-methyl-1H-imidazol-1-yl)pyridin-3-yl)-N4,5,5-trimethyl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine-2,4-diamine | US10669276, Example 18
Type:
Small organic molecule
Emp. Form.:
C23H28F2N8O
Mol. Mass.:
470.5182
SMILES:
CNc1nc(Nc2cnc(c(OC)c2)-n2cnc(C)c2)nc2N(CC(C)(C)c12)C1CC(F)(F)C1
Structure:
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