Reaction Details Report a problem with these data
Target
Amyloid-beta precursor protein [672-713]
Ligand
BDBM446540
Substrate
n/a
Meas. Tech.
gamma-Secretase Assay
EC50
11.0±n/a nM
Citation
 Bartels, B; Jakob-Roetne, R; Limberg, A; Neidhart, W; Ratni, H; Steiner, S; Reutlinger, M Fused pyrimidine derivatives US Patent  US10669276 Publication Date 6/2/2020 
Target
Name:
Amyloid-beta precursor protein [672-713]
Synonyms:
A4 | A4_HUMAN | AD1 | APP | Amyloid-beta precursor protein aa 672-713 | Amyloid-beta protein 42
Type:
Enzyme Catalytic Domain
Mol. Mass.:
4512.53
Organism:
Homo sapiens (Human)
Description:
P05067[672-713]
Residue:
42
Sequence:
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
  
Inhibitor
Name:
BDBM446540
Synonyms:
2-((2-((6-(4-Chloro-1H-imidazol-1-yl)-5-methoxypyridin-3-yl)amino)-7-(4-fluorophenyl)-5,5-dimethyl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)ethanol | US10669276, Example 30
Type:
Small organic molecule
Emp. Form.:
C25H26ClFN8O2
Mol. Mass.:
524.978
SMILES:
COc1cc(Nc2nc3N(CC(C)(C)c3c(NCCO)n2)c2ccc(F)cc2)cnc1-n1cnc(Cl)c1
Structure:
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