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Target
Proteasome subunit beta type-5
Ligand
BDBM446636
Substrate
n/a
Meas. Tech.
Determination of Beta5 Activity
IC50
>5000±n/a nM
Citation
 Klein, M; Schadt, O; Haselmayer, P; Krier, M Boronic acid derivatives US Patent  US10669289 Publication Date 6/2/2020 
Target
Name:
Proteasome subunit beta type-5
Synonyms:
20S proteasome chymotrypsin-like | 26S proteosome | LMPX | MB1 | PSB5_HUMAN | PSMB5 | Proteasome Macropain subunit MB1 | Proteasome subunit beta type-1/beta type-5 | X
Type:
Protein
Mol. Mass.:
28480.96
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
263
Sequence:
MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGTTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVADLHEKYSGSTP
  
Inhibitor
Name:
BDBM446636
Synonyms:
US10669289, Compound 43
Type:
Small organic molecule
Emp. Form.:
C21H23BF2N2O4
Mol. Mass.:
416.226
SMILES:
Cc1ccc(C[C@H](NC(=O)CN(C(=O)C=C)c2c(F)cccc2F)B(O)O)c(C)c1 |r|
Structure:
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