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Target
N-acylethanolamine-hydrolyzing acid amidase
Ligand
BDBM447502
Substrate
n/a
Meas. Tech.
Inhibition of Test Compounds NAAA Assay
IC50
550±n/a nM
Citation
 Malamas, MS; Makriyannis, A; Farah, SI; Zvonok, AM; Alapafuja, SO N-acylethanolamine hydrolyzing acid amidase (NAAA) inhibitors and use thereof US Patent  US10689357 Publication Date 6/23/2020 
Target
Name:
N-acylethanolamine-hydrolyzing acid amidase
Synonyms:
ASAH-like protein | ASAHL | Acid ceramidase-like protein | N-acylethanolamine-hydrolyzing acid amidase | N-acylsphingosine amidohydrolase-like | N-acylsphingosine-amidohydrolase | NAAA | NAAA_HUMAN | PLT
Type:
Enzyme
Mol. Mass.:
40073.12
Organism:
Homo sapiens (Human)
Description:
Q02083
Residue:
359
Sequence:
MRTADREARPGLPSLLLLLLAGAGLSAASPPAAPRFNVSLDSVPELRWLPVLRHYDLDLVRAAMAQVIGDRVPKWVHVLIGKVVLELERFLPQPFTGEIRGMCDFMNLSLADCLLVNLAYESSVFCTSIVAQDSRGHIYHGRNLDYPFGNVLRKLTVDVQFLKNGQIAFTGTTFIGYVGLWTGQSPHKFTVSGDERDKGWWWENAIAALFRRHIPVSWLIRATLSESENFEAAVGKLAKTPLIADVYYIVGGTSPREGVVITRNRDGPADIWPLDPLNGAWFRVETNYDHWKPAPKEDDRRTSAIKALNATGQANLSLEALFQILSVVPVYNNFTIYTTVMSAGSPDKYMTRIRNPSRK
  
Inhibitor
Name:
BDBM447502
Synonyms:
US10689357, Example 38
Type:
Small organic molecule
Emp. Form.:
C21H22N4O2S
Mol. Mass.:
394.49
SMILES:
COc1ccc(cc1)-c1cnc(C(=O)N[C@H]2C[C@H](C2)N=C=S)c(c1)N1CCC1 |r,wU:15.15,17.20,(-9.61,-3.78,;-8.28,-4.55,;-6.94,-3.78,;-6.94,-2.24,;-5.61,-1.47,;-4.28,-2.24,;-4.28,-3.78,;-5.61,-4.55,;-2.94,-1.47,;-1.61,-2.24,;-.28,-1.47,;-.28,.07,;1.06,.84,;1.06,2.38,;2.39,.07,;3.72,.84,;4.12,2.32,;5.61,1.93,;5.21,.44,;6.94,2.7,;8.28,3.47,;9.61,4.24,;-1.61,.84,;-2.94,.07,;-1.61,2.38,;-.52,3.47,;-1.61,4.55,;-2.7,3.47,)|
Structure:
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