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Target
Orexin receptor type 2
Ligand
BDBM185304
Substrate
n/a
Meas. Tech.
FLIPR Assay
IC50
>10000±n/a nM
Citation
 Fieldhouse, C; Glen, A; Maine, S; Fujimoto, T; Robinson, JS 1,2-substituted cyclopentanes as orexin receptor antagonists US Patent  US10689373 Publication Date 6/23/2020 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM185304
Synonyms:
US10011588, Example 123 | US10689373, Example 123 | US9156829, 123
Type:
Small organic molecule
Emp. Form.:
C19H17F4N7O
Mol. Mass.:
435.3782
SMILES:
Fc1cc(cnc1N[C@H]1CCC[C@@H]1NC(=O)c1ncccc1-n1nccn1)C(F)(F)F |r|
Structure:
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