Reaction Details Report a problem with these data
Target
Nicotinamide phosphoribosyltransferase
Ligand
BDBM449043
Substrate
n/a
Meas. Tech.
Enzymatic Reaction Assay
IC50
8.65±n/a nM
Citation
 Bair, KW; Baumeister, TR; Buckmelter, AJ; Clodfelter, KH; Dragovich, P; Gosselin, F; Gunzner-Toste, J; Han, B; Lin, J; Liu, X; Reynolds, DJ; Smith, CC; Wang, Z; Zak, M; Zhang, Y; Zhao, G; Zheng, X; Yuen, P Amido-benzyl sulfone and sulfoxide derivates US Patent  US10696692 Publication Date 6/30/2020 
Target
Name:
Nicotinamide phosphoribosyltransferase
Synonyms:
NAMPT | NAMPT_HUMAN | NAmPRTase | Nicotinamide phosphoribosyltransferase | Nicotinamide phosphoribosyltransferase (NAMPT) | PBEF | PBEF1 | Pre-B-cell colony-enhancing factor 1
Type:
Enzyme
Mol. Mass.:
55524.98
Organism:
Homo sapiens (Human)
Description:
P43490
Residue:
491
Sequence:
MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH
  
Inhibitor
Name:
BDBM449043
Synonyms:
Imidazo[1,2-a]pyrimidine- 6-carboxylic acid 4- (tetrahydro-pyran-4- sulfonyl)-benzylamide | US10696692, Example 199 | US10696692, Example 21
Type:
Small organic molecule
Emp. Form.:
C19H20N4O4S
Mol. Mass.:
400.451
SMILES:
O=C(NCc1ccc(cc1)S(=O)(=O)C1CCOCC1)c1cnc2nccn2c1
Structure:
Search PDB for entries with ligand similarity: