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Target
E3 ubiquitin-protein ligase Mdm2 [23-117]
Ligand
BDBM454381
Substrate
n/a
Meas. Tech.
AlphaScreen Assay
IC50
2.00±n/a nM
Citation
 Gollner, A; Broeker, J; Kerres, N; Kofink, C; Ramharter, J; Weinstabl, H; Gille, A; Goepper, S; Henry, M; Huchler, G Spiro[3H-indole-3,2′-pyrrolidin]-2(1H)-one compounds and derivatives as MDM2-P53 inhibitors US Patent  US10717742 Publication Date 7/21/2020 
Target
Name:
E3 ubiquitin-protein ligase Mdm2 [23-117]
Synonyms:
E3 ubiquitin-protein ligase Mdm2 (23-117) | MDM2 | MDM2 (aa 23-117) | MDM2_HUMAN
Type:
Oncoprotein
Mol. Mass.:
11177.88
Organism:
Homo sapiens (Human)
Description:
Q00987[23-117]
Residue:
95
Sequence:
EQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSD
  
Inhibitor
Name:
BDBM454381
Synonyms:
US10717742, Example Ia-38 | US10882866, Example Ia-38
Type:
Small organic molecule
Emp. Form.:
C30H23Cl2FN4O3
Mol. Mass.:
577.433
SMILES:
OC(=O)c1ccc2nn3[C@@H]4[C@H](Cc3c2c1)N(CC1CC1)[C@]1([C@H]4c2cccc(Cl)c2F)C(=O)Nc2cc(Cl)ccc12 |r|
Structure:
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