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Target
5-hydroxytryptamine receptor 3A
Ligand
BDBM299221
Substrate
n/a
Meas. Tech.
Inhibition of Ca Flux Activity of 5-HT3 In Vitro Assay
IC50
3.68±n/a nM
Citation
 Hitchcock, S; Monenschein, H; Reichard, H; Sun, H; Kikuchi, S; Macklin, T; Hopkins, M 5-HT3 receptor antagonists US Patent  US10125145 Publication Date 11/13/2018 
Target
Name:
5-hydroxytryptamine receptor 3A
Synonyms:
5-HT-3 | 5-HT3 | 5-HT3A | 5-HT3R | 5-hydroxytryptamine receptor 3 (5-HT3) | 5-hydroxytryptamine receptor 3A (5-HT3a) | 5-hydroxytryptamine receptor 3A (5HT3A) | 5HT3A_HUMAN | 5HT3R | HTR3 | HTR3A | Serotonin 3 (5-HT3) receptor | Serotonin 3 receptor (5HT3) | Serotonin receptor 3A | Serotonin-gated ion channel receptor | Serotonin-gated ion channel receptor 3
Type:
Protein
Mol. Mass.:
55283.27
Organism:
Homo sapiens (Human)
Description:
P46098
Residue:
478
Sequence:
MLLWVQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVMLWSIWQYA
  
Inhibitor
Name:
BDBM299221
Synonyms:
(1R,5S,7S)-3-oxa-9-azabicyclo [3.3.1]nonan-7-yl 1-(2- cyanopyridin-4-yl)-1H-indole- 3-carboxylate | US10125145, Cpd. No. 19
Type:
Small organic molecule
Emp. Form.:
C22H20N4O3
Mol. Mass.:
388.4192
SMILES:
O=C(OC1CC2COCC(C1)N2)c1cn(-c2ccnc(c2)C#N)c2ccccc12 |TLB:2:3:11:6.8.7|
Structure:
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