Reaction Details Report a problem with these data
Target
Mu-type opioid receptor
Ligand
BDBM457045
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
Ki
48.0±n/a nM
Citation
 Ratcliffe, P; Konetzki, I; Sitnikov, N; Koch, T; Jostock, R 1,3-diaza-spiro-[3.4]-octane derivatives US Patent  US10738015 Publication Date 8/11/2020 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM457045
Synonyms:
US10738015, Example SC-9
Type:
Small organic molecule
Emp. Form.:
C21H30N4O2
Mol. Mass.:
370.4885
SMILES:
CN(C)C1(CC2(C1)CN(CC(N)=O)C(=O)N2CC1CCC1)c1ccccc1 |(-3.15,.25,;-1.63,-.03,;-1.59,-1.57,;-.32,.77,;.77,-.32,;1.86,.77,;.77,1.86,;2.76,2.02,;4.23,1.54,;5.47,2.45,;5.31,3.98,;6.56,4.88,;3.91,4.6,;4.23,,;5.47,-.91,;2.76,-.48,;2.29,-1.94,;3.32,-3.09,;4.86,-3.17,;4.78,-4.7,;3.24,-4.62,;-1.63,1.57,;-2.99,.84,;-4.3,1.64,;-4.26,3.18,;-2.9,3.92,;-1.59,3.11,)|
Structure:
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