Reaction Details Report a problem with these data
Target
Mu-type opioid receptor
Ligand
BDBM457056
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
Ki
11.0±n/a nM
Citation
 Ratcliffe, P; Konetzki, I; Sitnikov, N; Koch, T; Jostock, R 1,3-diaza-spiro-[3.4]-octane derivatives US Patent  US10738015 Publication Date 8/11/2020 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM457056
Synonyms:
US10738015, Example SC-22
Type:
Small organic molecule
Emp. Form.:
C21H23F3N4O
Mol. Mass.:
404.4287
SMILES:
CN(C)C1(CC2(C1)CN(C(=O)N2)c1cnc(cc1C)C(F)F)c1cccc(F)c1 |(-1.59,3.11,;-1.63,1.57,;-3.15,1.29,;-.32,.77,;.77,-.32,;1.86,.77,;.77,1.86,;2.76,2.02,;4.23,1.54,;4.23,,;5.47,-.91,;2.76,-.48,;5.47,2.45,;5.31,3.98,;6.56,4.88,;7.97,4.26,;8.13,2.72,;6.88,1.82,;7.04,.29,;9.21,5.16,;9.05,6.69,;10.62,4.53,;-1.63,-.03,;-2.99,.7,;-4.3,-.1,;-4.26,-1.64,;-2.9,-2.38,;-2.86,-3.92,;-1.59,-1.57,)|
Structure:
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