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Target
Nociceptin receptor
Ligand
BDBM457071
Substrate
n/a
Meas. Tech.
Scintillation Proximity Assay
Ki
6.00±n/a nM
Citation
 Ratcliffe, P; Konetzki, I; Sitnikov, N; Koch, T; Jostock, R 1,3-diaza-spiro-[3.4]-octane derivatives US Patent  US10738015 Publication Date 8/11/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM457071
Synonyms:
Cis-5-[5-(cyclopropylmethyl)- 2-(dimethylamino)-6-oxo-2- phenyl-5,7- diazaspiro[3.4]octan-7-yl]-3- (trifluoromethyl)pyridine-2- carbonitrile | US10738015, Example SC-40
Type:
Small organic molecule
Emp. Form.:
C25H26F3N5O
Mol. Mass.:
469.502
SMILES:
CN(C)[C@]1(C[C@@]2(C1)CN(C(=O)N2CC1CC1)c1cnc(C#N)c(c1)C(F)(F)F)c1ccccc1 |r,wU:5.5,3.2,(3.78,1.17,;4.1,-.34,;5.57,-.82,;2.96,-1.37,;1.81,-2.4,;.78,-1.26,;1.93,-.23,;.16,.15,;-1.37,-.01,;-1.69,-1.52,;-3.1,-2.14,;-.36,-2.29,;.04,-3.77,;-1.05,-4.86,;-2.54,-5.26,;-1.45,-6.35,;-2.4,1.13,;-3.91,.81,;-4.94,1.96,;-4.47,3.42,;-5.5,4.57,;-6.53,5.71,;-2.96,3.74,;-1.93,2.6,;-2.48,5.21,;-.98,5.53,;-3.51,6.35,;-1.45,4.06,;3.99,-2.52,;5.5,-2.2,;6.53,-3.34,;6.05,-4.8,;4.54,-5.12,;3.51,-3.98,)|
Structure:
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