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Target
Nociceptin receptor
Ligand
BDBM457075
Substrate
n/a
Meas. Tech.
Scintillation Proximity Assay
Ki
15.0±n/a nM
Citation
 Ratcliffe, P; Konetzki, I; Sitnikov, N; Koch, T; Jostock, R 1,3-diaza-spiro-[3.4]-octane derivatives US Patent  US10738015 Publication Date 8/11/2020 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM457075
Synonyms:
US10738015, Example SC-44
Type:
Small organic molecule
Emp. Form.:
C21H27FN4O
Mol. Mass.:
370.4637
SMILES:
CN(C)C1(CC2(C1)CN(CCC#N)C(=O)N2CC1CC1)c1cccc(F)c1 |(-3.15,.25,;-1.63,-.03,;-1.59,-1.57,;-.32,.77,;.77,-.32,;1.86,.77,;.77,1.86,;2.76,2.02,;4.23,1.54,;5.47,2.45,;5.31,3.98,;3.91,4.6,;2.5,5.23,;4.23,,;5.47,-.91,;2.76,-.48,;2.29,-1.94,;3.32,-3.09,;4.78,-3.56,;3.64,-4.59,;-1.63,1.57,;-1.59,3.11,;-2.9,3.92,;-4.26,3.18,;-4.3,1.64,;-5.65,.91,;-2.99,.84,)|
Structure:
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