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Target
Tyrosine-protein kinase JAK2 [808-1132]
Ligand
BDBM127757
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
>1000±n/a nM
Citation
 Allen, S; Andrews, SW; Condroski, KR; Haas, J; Huang, L; Jiang, Y; Kercher, T; Seo, J Substituted pyrazolo[l,5-a]pyrimidine compounds as Trk kinase inhibitors US Patent  US10758542 Publication Date 9/1/2020 
Target
Name:
Tyrosine-protein kinase JAK2 [808-1132]
Synonyms:
JAK2 | JAK2_HUMAN | Janus kinase 2 (JAK2) | Tyrosine-protein kinase JAK2 | Tyrosine-protein kinase JAK2 (808-1132)
Type:
n/a
Mol. Mass.:
37984.02
Organism:
Homo sapiens (Human)
Description:
808-1132 aa of O60674
Residue:
325
Sequence:
LFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
  
Inhibitor
Name:
BDBM127757
Synonyms:
US10251889, Example 130 | US10758542, Example 130 | US8791123, 130 | US9782415, Example 130 | US9796724, Example 130
Type:
Small organic molecule
Emp. Form.:
C19H18F4N6O
Mol. Mass.:
422.3794
SMILES:
C[C@H](NC(=O)c1cnn2ccc(nc12)N1CCCC1c1cncc(F)c1)C(F)(F)F |r|
Structure:
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