Reaction Details Report a problem with these data
Target
Glutamate dehydrogenase 2, mitochondrial
Ligand
BDBM108951
Substrate
n/a
Meas. Tech.
Recombinant Enzyme Assay - Time Dependence
IC50
7.00±n/a nM
Citation
 Li, J; Chen, L; Goyal, B; Laidig, G; Stanton, TF; Sjogren, EB Heterocyclic glutaminase inhibitors US Patent  US10793535 Publication Date 10/6/2020 
Target
Name:
Glutamate dehydrogenase 2, mitochondrial
Synonyms:
DHE4_HUMAN | GDH 2 | GLUD2 | GLUDP1
Type:
Protein
Mol. Mass.:
61446.88
Organism:
Human
Description:
P49448
Residue:
558
Sequence:
MYRYLAKALLPSRAGPAALGSAANHSAALLGRGRGQPAAASQPGLALAARRHYSELVADREDDPNFFKMVEGFFDRGASIVEDKLVKDLRTQESEEQKRNRVRGILRIIKPCNHVLSLSFPIRRDDGSWEVIEGYRAQHSQHRTPCKGGIRYSTDVSVDEVKALASLMTYKCAVVDVPFGGAKAGVKINPKNYTENELEKITRRFTMELAKKGFIGPGVDVPAPDMNTGEREMSWIADTYASTIGHYDINAHACVTGKPISQGGIHGRISATGRGVFHGIENFINEASYMSILGMTPGFRDKTFVVQGFGNVGLHSMRYLHRFGAKCIAVGESDGSIWNPDGIDPKELEDFKLQHGSILGFPKAKPYEGSILEVDCDILIPAATEKQLTKSNAPRVKAKIIAEGANGPTTPEADKIFLERNILVIPDLYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLLSVQESLERKFGKHGGTIPIVPTAEFQDSISGASEKDIVHSALAYTMERSARQIMHTAMKYNLGLDLRTAAYVNAIEKVFKVYSEAGVTFT
  
Inhibitor
Name:
BDBM108951
Synonyms:
US10793535, Cmpd ID 533 | US8604016, 533 | US9938267, Cmpd ID 533
Type:
Small organic molecule
Emp. Form.:
C26H24ClFN6O2S
Mol. Mass.:
539.024
SMILES:
Fc1ccccc1CC(=O)Nc1nnc(CCCCc2ccc(NC(=O)Cc3ccccc3Cl)nn2)s1
Structure:
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