Reaction Details Report a problem with these data
Target
Glutamate dehydrogenase 2, mitochondrial
Ligand
BDBM109034
Substrate
n/a
Meas. Tech.
Recombinant Enzyme Assay - Time Dependence
IC50
8.00±n/a nM
Citation
 Li, J; Chen, L; Goyal, B; Laidig, G; Stanton, TF; Sjogren, EB Heterocyclic glutaminase inhibitors US Patent  US10793535 Publication Date 10/6/2020 
Target
Name:
Glutamate dehydrogenase 2, mitochondrial
Synonyms:
DHE4_HUMAN | GDH 2 | GLUD2 | GLUDP1
Type:
Protein
Mol. Mass.:
61446.88
Organism:
Human
Description:
P49448
Residue:
558
Sequence:
MYRYLAKALLPSRAGPAALGSAANHSAALLGRGRGQPAAASQPGLALAARRHYSELVADREDDPNFFKMVEGFFDRGASIVEDKLVKDLRTQESEEQKRNRVRGILRIIKPCNHVLSLSFPIRRDDGSWEVIEGYRAQHSQHRTPCKGGIRYSTDVSVDEVKALASLMTYKCAVVDVPFGGAKAGVKINPKNYTENELEKITRRFTMELAKKGFIGPGVDVPAPDMNTGEREMSWIADTYASTIGHYDINAHACVTGKPISQGGIHGRISATGRGVFHGIENFINEASYMSILGMTPGFRDKTFVVQGFGNVGLHSMRYLHRFGAKCIAVGESDGSIWNPDGIDPKELEDFKLQHGSILGFPKAKPYEGSILEVDCDILIPAATEKQLTKSNAPRVKAKIIAEGANGPTTPEADKIFLERNILVIPDLYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLLSVQESLERKFGKHGGTIPIVPTAEFQDSISGASEKDIVHSALAYTMERSARQIMHTAMKYNLGLDLRTAAYVNAIEKVFKVYSEAGVTFT
  
Inhibitor
Name:
BDBM109034
Synonyms:
US10793535, Cmpd ID 616 | US8604016, 616 | US9938267, Cmpd ID 616
Type:
Small organic molecule
Emp. Form.:
C27H28N6O2S
Mol. Mass.:
500.615
SMILES:
CC(C(=O)Nc1nnc(CCCCc2ccc(NC(=O)Cc3ccccc3)nn2)s1)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: