Reaction Details Report a problem with these data
Target
Glutamate dehydrogenase 2, mitochondrial
Ligand
BDBM383189
Substrate
n/a
Meas. Tech.
Modified Recombinant Enzyme Assay
IC50
34.0±n/a nM
Citation
 Li, J; Chen, L; Goyal, B; Laidig, G; Stanton, TF; Sjogren, EB Heterocyclic glutaminase inhibitors US Patent  US10793535 Publication Date 10/6/2020 
Target
Name:
Glutamate dehydrogenase 2, mitochondrial
Synonyms:
DHE4_HUMAN | GDH 2 | GLUD2 | GLUDP1
Type:
Protein
Mol. Mass.:
61446.88
Organism:
Human
Description:
P49448
Residue:
558
Sequence:
MYRYLAKALLPSRAGPAALGSAANHSAALLGRGRGQPAAASQPGLALAARRHYSELVADREDDPNFFKMVEGFFDRGASIVEDKLVKDLRTQESEEQKRNRVRGILRIIKPCNHVLSLSFPIRRDDGSWEVIEGYRAQHSQHRTPCKGGIRYSTDVSVDEVKALASLMTYKCAVVDVPFGGAKAGVKINPKNYTENELEKITRRFTMELAKKGFIGPGVDVPAPDMNTGEREMSWIADTYASTIGHYDINAHACVTGKPISQGGIHGRISATGRGVFHGIENFINEASYMSILGMTPGFRDKTFVVQGFGNVGLHSMRYLHRFGAKCIAVGESDGSIWNPDGIDPKELEDFKLQHGSILGFPKAKPYEGSILEVDCDILIPAATEKQLTKSNAPRVKAKIIAEGANGPTTPEADKIFLERNILVIPDLYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLLSVQESLERKFGKHGGTIPIVPTAEFQDSISGASEKDIVHSALAYTMERSARQIMHTAMKYNLGLDLRTAAYVNAIEKVFKVYSEAGVTFT
  
Inhibitor
Name:
BDBM383189
Synonyms:
US10278968, Compound 717 | US10793535, Cmpd ID 717
Type:
Small organic molecule
Emp. Form.:
C27H26F3N7O4S
Mol. Mass.:
601.6
SMILES:
COc1ccc(OC(F)(F)F)cc1CC(=O)Nc1ccc(CCCCc2nnc(NC(=O)Cc3ccccn3)s2)nn1
Structure:
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