Reaction Details Report a problem with these data
Target
Glutamate dehydrogenase 2, mitochondrial
Ligand
BDBM383191
Substrate
n/a
Meas. Tech.
Modified Recombinant Enzyme Assay
IC50
33.0±n/a nM
Citation
 Li, J; Chen, L; Goyal, B; Laidig, G; Stanton, TF; Sjogren, EB Heterocyclic glutaminase inhibitors US Patent  US10793535 Publication Date 10/6/2020 
Target
Name:
Glutamate dehydrogenase 2, mitochondrial
Synonyms:
DHE4_HUMAN | GDH 2 | GLUD2 | GLUDP1
Type:
Protein
Mol. Mass.:
61446.88
Organism:
Human
Description:
P49448
Residue:
558
Sequence:
MYRYLAKALLPSRAGPAALGSAANHSAALLGRGRGQPAAASQPGLALAARRHYSELVADREDDPNFFKMVEGFFDRGASIVEDKLVKDLRTQESEEQKRNRVRGILRIIKPCNHVLSLSFPIRRDDGSWEVIEGYRAQHSQHRTPCKGGIRYSTDVSVDEVKALASLMTYKCAVVDVPFGGAKAGVKINPKNYTENELEKITRRFTMELAKKGFIGPGVDVPAPDMNTGEREMSWIADTYASTIGHYDINAHACVTGKPISQGGIHGRISATGRGVFHGIENFINEASYMSILGMTPGFRDKTFVVQGFGNVGLHSMRYLHRFGAKCIAVGESDGSIWNPDGIDPKELEDFKLQHGSILGFPKAKPYEGSILEVDCDILIPAATEKQLTKSNAPRVKAKIIAEGANGPTTPEADKIFLERNILVIPDLYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLLSVQESLERKFGKHGGTIPIVPTAEFQDSISGASEKDIVHSALAYTMERSARQIMHTAMKYNLGLDLRTAAYVNAIEKVFKVYSEAGVTFT
  
Inhibitor
Name:
BDBM383191
Synonyms:
US10278968, Compound 719 | US10793535, Cmpd ID 719
Type:
Small organic molecule
Emp. Form.:
C26H23F4N7O3S
Mol. Mass.:
589.565
SMILES:
Fc1ccc(CC(=O)Nc2ccc(CCCCc3nnc(NC(=O)Cc4ccccn4)s3)nn2)cc1OC(F)(F)F
Structure:
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