Reaction Details
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Probable integral membrane cytochrome D ubiquinol oxidase (Subunit II) CydB (Cytochrome BD-I oxidase subunit II)
Ligand
BDBM466331
Substrate
n/a
Meas. Tech.
Mtb cytochrome bd inhibition assay
IC50
750±360 nM
Citation
Biagini, GA; Ward, SA; Nixon, GL; O''Neill, PM Combination of respiratory electron transport chain inhibitors with a cytochrome bd inhibitor US Patent US10799494 Publication Date 10/13/2020 More Info.:
Target
Name:
Probable integral membrane cytochrome D ubiquinol oxidase (Subunit II) CydB (Cytochrome BD-I oxidase subunit II)
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
37630.78
Organism:
n/a
Description:
O06139
Residue:
346
Sequence:
MVLQELWFGVIAALFLGFFILEGFDFGVGMLMAPFAHVGMGDPETHRRTALNTIGPVWDGNEVWLITAGAAIFAAFPGWYATVFSALYLPLLAILFGMILRAVAIEWRGKIDDPKWRTGADFGIAAGSWLPALLWGVAFAILVRGLPVDANGHVALSIPDVLNAYTLLGGLATAGLFSLYGAVFIALKTSGPIRDDAYRFAVWLSLPVAGLVAGFGLWTQLAYGKDWTWLVLAVAGCAQAAATVLVWRRVSDGWAFMCTLIVVAAVVVLLFGALYPNLVPSTLNPQWSLTIHNASSTPYTLKIMTWVTAFFAPLTVAYQTWTYWVFRQRISAERIPPPTGLARRAP
Inhibitor
Name:
BDBM466331
Synonyms:
US10799494, Compound RKA-70
Type:
Small organic molecule
Emp. Form.:
C23H16F3NO2
Mol. Mass.:
395.3738
SMILES:
FC(F)(F)Oc1ccc(Cc2ccc(cc2)-c2cc(=O)c3ccccc3[nH]2)cc1
Structure:
