Reaction Details
Report a problem with these data
Report a problem with these dataTarget
Probable integral membrane cytochrome D ubiquinol oxidase (Subunit II) CydB (Cytochrome BD-I oxidase subunit II)
Ligand
BDBM466336
Substrate
n/a
Meas. Tech.
Mtb cytochrome bd inhibition assay
IC50
290±70 nM
Citation
Biagini, GA; Ward, SA; Nixon, GL; O''Neill, PM Combination of respiratory electron transport chain inhibitors with a cytochrome bd inhibitor US Patent US10799494 Publication Date 10/13/2020 More Info.:
Target
Name:
Probable integral membrane cytochrome D ubiquinol oxidase (Subunit II) CydB (Cytochrome BD-I oxidase subunit II)
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
37630.78
Organism:
n/a
Description:
O06139
Residue:
346
Sequence:
MVLQELWFGVIAALFLGFFILEGFDFGVGMLMAPFAHVGMGDPETHRRTALNTIGPVWDGNEVWLITAGAAIFAAFPGWYATVFSALYLPLLAILFGMILRAVAIEWRGKIDDPKWRTGADFGIAAGSWLPALLWGVAFAILVRGLPVDANGHVALSIPDVLNAYTLLGGLATAGLFSLYGAVFIALKTSGPIRDDAYRFAVWLSLPVAGLVAGFGLWTQLAYGKDWTWLVLAVAGCAQAAATVLVWRRVSDGWAFMCTLIVVAAVVVLLFGALYPNLVPSTLNPQWSLTIHNASSTPYTLKIMTWVTAFFAPLTVAYQTWTYWVFRQRISAERIPPPTGLARRAP
Inhibitor
Name:
BDBM466336
Synonyms:
US10799494, Compound SL-2-25
Type:
Small organic molecule
Emp. Form.:
C22H15F3N2O2
Mol. Mass.:
396.3619
SMILES:
Cc1c([nH]c2ccccc2c1=O)-c1ccc(nc1)-c1ccc(OC(F)(F)F)cc1
Structure:
