Reaction Details
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Probable integral membrane cytochrome D ubiquinol oxidase (Subunit II) CydB (Cytochrome BD-I oxidase subunit II)
Ligand
BDBM466342
Substrate
n/a
Meas. Tech.
Mtb cytochrome bd inhibition assay
IC50
2020±n/a nM
Citation
Biagini, GA; Ward, SA; Nixon, GL; O''Neill, PM Combination of respiratory electron transport chain inhibitors with a cytochrome bd inhibitor US Patent US10799494 Publication Date 10/13/2020 More Info.:
Target
Name:
Probable integral membrane cytochrome D ubiquinol oxidase (Subunit II) CydB (Cytochrome BD-I oxidase subunit II)
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
37630.78
Organism:
n/a
Description:
O06139
Residue:
346
Sequence:
MVLQELWFGVIAALFLGFFILEGFDFGVGMLMAPFAHVGMGDPETHRRTALNTIGPVWDGNEVWLITAGAAIFAAFPGWYATVFSALYLPLLAILFGMILRAVAIEWRGKIDDPKWRTGADFGIAAGSWLPALLWGVAFAILVRGLPVDANGHVALSIPDVLNAYTLLGGLATAGLFSLYGAVFIALKTSGPIRDDAYRFAVWLSLPVAGLVAGFGLWTQLAYGKDWTWLVLAVAGCAQAAATVLVWRRVSDGWAFMCTLIVVAAVVVLLFGALYPNLVPSTLNPQWSLTIHNASSTPYTLKIMTWVTAFFAPLTVAYQTWTYWVFRQRISAERIPPPTGLARRAP
Inhibitor
Name:
BDBM466342
Synonyms:
US10799494, Example RKA 142
Type:
Small organic molecule
Emp. Form.:
C22H15F3N2O
Mol. Mass.:
380.3625
SMILES:
Cc1c([nH]c2ccccc2c1=O)-c1ccc(nc1)-c1ccc(cc1)C(F)(F)F
Structure:
