Reaction Details Report a problem with these data
Target
Cannabinoid receptor 1
Ligand
BDBM300134
Substrate
n/a
EC50
>10000±n/a nM
Citation
 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A Triazolo[4,5-D]pyrimidine derivatives US Patent  US9593123 Publication Date 3/14/2017 
Target
Name:
Cannabinoid receptor 1
Synonyms:
CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52868.96
Organism:
Homo sapiens (Human)
Description:
P21554
Residue:
472
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
  
Inhibitor
Name:
BDBM300134
Synonyms:
(3S)-1-[3-[(2-Chlorophenyl)methyl]-5-prop-1-en-2-yltriazolo[4,5-d]pyrimidin-7-yl]pyrrolidin-3-ol | US9593123, Example 6
Type:
Small organic molecule
Emp. Form.:
C18H19ClN6O
Mol. Mass.:
370.836
SMILES:
CC(=C)c1nc(N2CC[C@H](O)C2)c2nnn(Cc3ccccc3Cl)c2n1 |r|
Structure:
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