Reaction Details Report a problem with these data
Target
Cannabinoid receptor 1
Ligand
BDBM300152
Substrate
n/a
EC50
487±n/a nM
Citation
 Grether, U; Nettekoven, M; Rogers-Evans, M; Roever, S; Schmitt, S; Kimbara, A Triazolo[4,5-D]pyrimidine derivatives US Patent  US9593123 Publication Date 3/14/2017 
Target
Name:
Cannabinoid receptor 1
Synonyms:
CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52868.96
Organism:
Homo sapiens (Human)
Description:
P21554
Residue:
472
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
  
Inhibitor
Name:
BDBM300152
Synonyms:
N-tert-Butyl-7-(3,3-difluoropyrrolidin-1-yl)-3-[(2-methyl sulfonylphenyl)methyl]triazolo[4,5-d]pyrimidin-5-amine | US9593123, Example 23
Type:
Small organic molecule
Emp. Form.:
C20H25F2N7O2S
Mol. Mass.:
465.52
SMILES:
CC(C)(C)Nc1nc(N2CCC(F)(F)C2)c2nnn(Cc3ccccc3S(C)(=O)=O)c2n1
Structure:
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