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Target
Serine/threonine-protein kinase Chk1
Ligand
BDBM411557
Substrate
n/a
Meas. Tech.
pCHK1 Cellular Assay
IC50
110±n/a nM
Citation
 Di Francesco, ME; Jones, P; Carroll, CL; Cross, JB; Ramaswamy, SK; Johnson, MG; Lively, S; Lapointe, D Heterocyclic inhibitors of ATR kinase US Patent  US10800769 Publication Date 10/13/2020 
Target
Name:
Serine/threonine-protein kinase Chk1
Synonyms:
CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
54443.02
Organism:
Homo sapiens (Human)
Description:
gi_166295192
Residue:
476
Sequence:
MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDFSPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLLGTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRRNNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
  
Inhibitor
Name:
BDBM411557
Synonyms:
(R)-((2-(5-fluoro-2- methyl-1H-benzo[d]- imidazol-1-yl)-6-(3- methylmorpholino)- pyrimidin-4-yl)imino)- dimethyl-lambda6-sulfanone | US10392376, Example 108 | US10800769, Example 108 | US11434233, Example 108
Type:
Small organic molecule
Emp. Form.:
C19H23FN6O2S
Mol. Mass.:
418.488
SMILES:
C[C@@H]1COCCN1c1cc(N=S(C)(C)=O)nc(n1)-n1c(C)nc2cc(F)ccc12 |r|
Structure:
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