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Target
Disabled homolog 2
Ligand
BDBM50262140
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Assay
Ki
1260±n/a nM
Citation
 Madden, DR Dab2 inhibitors for the prevention and treatment of cystic fibrosis US Patent  US10864248 Publication Date 12/15/2020 
Target
Name:
Disabled homolog 2
Synonyms:
Adaptor molecule disabled-2 | DAB2 | DAB2_HUMAN | DOC-2 | DOC2 | Differentially expressed in ovarian carcinoma 2 | Differentially-expressed protein 2
Type:
Protein
Mol. Mass.:
82438.29
Organism:
Human
Description:
P98082
Residue:
770
Sequence:
MSNEVETSATNGQPDQQAAPKAPSKKEKKKGPEKTDEYLLARFKGDGVKYKAKLIGIDDVPDARGDKMSQDSMMKLKGMAAAGRSQGQHKQRIWVNISLSGIKIIDEKTGVIEHEHPVNKISFIARDVTDNRAFGYVCGGEGQHQFFAIKTGQQAEPLVVDLKDLFQVIYNVKKKEEEKKKIEEASKAVENGSEALMILDDQTNKLKSGVDQMDLFGDMSTPPDLNSPTESKDILLVDLNSEIDTNQNSLRENPFLTNGITSCSLPRPTPQASFLPENAFSANLNFFPTPNPDPFRDDPFTQPDQSTPSSFDSLKSPDQKKENSSSSSTPLSNGPLNGDVDYFGQQFDQISNRTGKQEAQAGPWPFSSSQTQPAVRTQNGVSEREQNGFSVKSSPNPFVGSPPKGLSIQNGVKQDLESSVQSSPHDSIAIIPPPQSTKPGRGRRTAKSSANDLLASDIFAPPVSEPSGQASPTGQPTALQPNPLDLFKTSAPAPVGPLVGLGGVTVTLPQAGPWNTASLVFNQSPSMAPGAMMGGQPSGFSQPVIFGTSPAVSGWNQPSPFAASTPPPVPVVWGPSASVAPNAWSTTSPLGNPFQSNIFPAPAVSTQPPSMHSSLLVTPPQPPPRAGPPKDISSDAFTALDPLGDKEIKDVKEMFKDFQLRQPPAVPARKGEQTSSGTLSAFASYFNSKVGIPQENADHDDFDANQLLNKINEPPKPAPRQVSLPVTKSTDNAFENPFFKDSFGSSQASVASSQPVSSEMYRDPFGNPFA
  
Inhibitor
Name:
BDBM50262140
Synonyms:
(17beta)-estra-1,3,5(10)-triene-2,3,17-triol | 2-OH-E2 | 2-OH-estradiol | 2-hydroxy-17beta-estradiol | CHEMBL467987 | US10864248, Compound 2 | cid_247304 | estra-1,3,5(10)-triene-2,3,17beta-triol
Type:
Small organic molecule
Emp. Form.:
C18H24O3
Mol. Mass.:
288.3814
SMILES:
C[C@]12CC[C@H]3[C@@H](CCc4cc(O)c(O)cc34)[C@@H]1CC[C@@H]2O |r|
Structure:
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