Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM300807
Substrate
n/a
Meas. Tech.
GPR40 Calcium Flux Assay
EC50
23.0±n/a nM
Citation
 Huang, H; Kuo, G; Player, MR; Yang, S; Zhang, Y Substituted benzothiophenyl derivatives as GPR40 agonists for the treatment of type II diabetes US Patent  US10131648 Publication Date 11/20/2018 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM300807
Synonyms:
(3S)-3-[4-[[3-[4-(1,1-Dioxo-1,4- thiazinane-4-carbonyl)-2- methyl- phenyl]benzo[b]thiophen-5- yl]methoxy]phenyl] hex-4-ynoic acid | US10131648, Compound 5 | US10195178, Compound 5 | US9790198, Compound 5
Type:
Small organic molecule
Emp. Form.:
C33H31NO6S2
Mol. Mass.:
601.732
SMILES:
CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc3scc(-c4ccc(cc4C)C(=O)N4CCS(=O)(=O)CC4)c3c2)cc1 |r|
Structure:
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