Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM300834
Substrate
n/a
Meas. Tech.
GPR40 Calcium Flux Assay
EC50
36.0±n/a nM
Citation
 Huang, H; Kuo, G; Player, MR; Yang, S; Zhang, Y Substituted benzothiophenyl derivatives as GPR40 agonists for the treatment of type II diabetes US Patent  US10131648 Publication Date 11/20/2018 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM300834
Synonyms:
2-(1-(4-((3-(4-(2- Ethoxyethoxy)-2- methylphenyl)benzo[b]thiophen- 5-yl)methoxy)phenyl)-3- oxocyclobutyl)acetic acid | US10131648, Compound 32 | US10195178, Compound 32 | US9790198, Compound 32
Type:
Small organic molecule
Emp. Form.:
C32H32O6S
Mol. Mass.:
544.658
SMILES:
CCOCCOc1ccc(-c2csc3ccc(COc4ccc(cc4)C4(CC(O)=O)CC(=O)C4)cc23)c(C)c1
Structure:
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