Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM300835
Substrate
n/a
Meas. Tech.
GPR40 Calcium Flux Assay
EC50
15.0±n/a nM
Citation
 Huang, H; Kuo, G; Player, MR; Yang, S; Zhang, Y Substituted benzothiophenyl derivatives as GPR40 agonists for the treatment of type II diabetes US Patent  US10131648 Publication Date 11/20/2018 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM300835
Synonyms:
2-(1-(4-((3-(4-((1,1- Dioxidotetrahydro-2H- thiopyran-4-yl)oxy)-2- methylphenyl)benzo[b]thiophen- 5-yl)methoxy)phenyl)-3- oxocyclobutyl)acetic acid | US10131648, Compound 33 | US10195178, Compound 33 | US9790198, Compound 33
Type:
Small organic molecule
Emp. Form.:
C33H32O7S2
Mol. Mass.:
604.733
SMILES:
Cc1cc(OC2CCS(=O)(=O)CC2)ccc1-c1csc2ccc(COc3ccc(cc3)C3(CC(O)=O)CC(=O)C3)cc12
Structure:
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