Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM300837
Substrate
n/a
Meas. Tech.
GPR40 Calcium Flux Assay
EC50
26.0±n/a nM
Citation
 Huang, H; Kuo, G; Player, MR; Yang, S; Zhang, Y Substituted benzothiophenyl derivatives as GPR40 agonists for the treatment of type II diabetes US Patent  US10131648 Publication Date 11/20/2018 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM300837
Synonyms:
2-((1r,3r)-3-Hydroxy-1-(4-((3- (4-(2-ethoxyethoxy)-2- methylphenyl) benzo[b]thiophen-5- yl)methoxy)phenyl)cyclobutyl) acetic acid | US10131648, Compound 35 | US10195178, Compound 35 | US9790198, Compound 35
Type:
Small organic molecule
Emp. Form.:
C32H34O6S
Mol. Mass.:
546.674
SMILES:
CCOCCOc1ccc(-c2csc3ccc(COc4ccc(cc4)[C@@]4(CC(O)=O)C[C@H](O)C4)cc23)c(C)c1 |r,wU:25.25,wD:31.32,(-5.38,-7.49,;-6.47,-6.4,;-6.07,-4.91,;-7.16,-3.82,;-6.76,-2.34,;-7.85,-1.25,;-7.45,.24,;-8.54,1.33,;-8.14,2.82,;-6.66,3.22,;-6.26,4.7,;-7.16,5.95,;-6.26,7.19,;-4.79,6.72,;-3.46,7.49,;-2.13,6.72,;-2.13,5.18,;-.79,4.41,;-.79,2.87,;.54,2.1,;.54,.56,;1.87,-.21,;3.21,.56,;3.21,2.1,;1.87,2.87,;4.54,-.21,;5.88,.56,;7.21,-.21,;8.54,.56,;7.21,-1.75,;5.63,-1.3,;4.54,-2.39,;4.54,-3.93,;3.45,-1.3,;-3.46,4.41,;-4.79,5.18,;-5.57,2.13,;-4.08,2.53,;-5.97,.64,)|
Structure:
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