Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM300838
Substrate
n/a
Meas. Tech.
GPR40 Calcium Flux Assay
EC50
43.0±n/a nM
Citation
 Huang, H; Kuo, G; Player, MR; Yang, S; Zhang, Y Substituted benzothiophenyl derivatives as GPR40 agonists for the treatment of type II diabetes US Patent  US10131648 Publication Date 11/20/2018 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM300838
Synonyms:
2-((1r,3r)-1-(4-((3-(4-((1,1- Dioxidotetrahydro-2H- thiopyran-4-yl)oxy)-2- methylphenyl)benzo[b]thiophen- 5-yl)methoxy)phenyl)-3- hydroxycyclobutyl)acetic acid | US10131648, Compound 36 | US10195178, Compound 36 | US9790198, Compound 36
Type:
Small organic molecule
Emp. Form.:
C33H34O7S2
Mol. Mass.:
606.749
SMILES:
Cc1cc(OC2CCS(=O)(=O)CC2)ccc1-c1csc2ccc(COc3ccc(cc3)[C@@]3(CC(O)=O)C[C@H](O)C3)cc12 |r,wU:31.33,wD:37.40,(-1.69,.18,;-3.18,-.22,;-3.58,-1.7,;-5.07,-2.1,;-5.46,-3.59,;-6.95,-3.99,;-8.04,-2.9,;-9.53,-3.3,;-9.93,-4.79,;-11.41,-4.39,;-11.02,-5.87,;-8.84,-5.87,;-7.35,-5.48,;-6.15,-1.01,;-5.76,.47,;-4.27,.87,;-3.87,2.36,;-5.12,3.27,;-4.64,4.73,;-3.1,4.73,;-2.07,5.87,;-.56,5.55,;-.09,4.09,;1.4,3.69,;1.8,2.2,;3.29,1.81,;3.68,.32,;5.17,-.08,;6.26,1.01,;5.86,2.5,;4.38,2.89,;7.75,.61,;8.84,1.7,;10.33,1.3,;11.41,2.39,;10.72,-.19,;9.08,-.16,;8.31,-1.49,;8.71,-2.98,;6.98,-.72,;-1.12,2.95,;-2.62,3.27,)|
Structure:
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