Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM300841
Substrate
n/a
Meas. Tech.
GPR40 Calcium Flux Assay
EC50
46.0±n/a nM
Citation
 Huang, H; Kuo, G; Player, MR; Yang, S; Zhang, Y Substituted benzothiophenyl derivatives as GPR40 agonists for the treatment of type II diabetes US Patent  US10131648 Publication Date 11/20/2018 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM300841
Synonyms:
2-((1r,3r)-3-Hydroxy-1-(4-((3- (2-methylpyridin-3- yl)benzo[b]thiophen-5- yl)methoxy)phenyl)cyclobutyl) acetic acid | US10131648, Compound 39 | US10195178, Compound 39 | US9790198, Compound 39
Type:
Small organic molecule
Emp. Form.:
C27H25NO4S
Mol. Mass.:
459.557
SMILES:
Cc1ncccc1-c1csc2ccc(COc3ccc(cc3)[C@@]3(CC(O)=O)C[C@H](O)C3)cc12 |r,wU:22.23,wD:28.30,(-4.32,-1.26,;-5.81,-1.66,;-6.21,-3.15,;-7.7,-3.55,;-8.78,-2.46,;-8.39,-.97,;-6.9,-.57,;-6.5,.91,;-7.75,1.82,;-7.27,3.28,;-5.73,3.28,;-4.7,4.43,;-3.19,4.11,;-2.72,2.64,;-1.23,2.24,;-.83,.76,;.66,.36,;1.06,-1.13,;2.54,-1.53,;3.63,-.44,;3.23,1.05,;1.75,1.45,;5.12,-.84,;6.21,.25,;7.7,-.15,;8.78,.94,;8.09,-1.63,;6.45,-1.61,;5.68,-2.94,;6.08,-4.43,;4.35,-2.17,;-3.75,1.5,;-5.25,1.82,)|
Structure:
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